Boeken
Slaapproblemen? Auteurs: Marcel Smits en Wiebe Braam Uitgever: Poiesz Uitgevers, Serie Spreekuur Thuis ISBN 9789066112292 Momenteel alleen tweedehands leverbaar (o.a. www.bol.com) Slaapproblemen komen voor bij mensen van alle leeftijden: kinderen, jongvolwassenen, senioren en hoogbejaarden. Stoornissen in het slaap-waakritme ontstaan als de biologische klok en de leefwijze niet goed op elkaar zijn afgestemd. Als gevolg hiervan kunnen allerlei klachten op het gebied van gezondheid en dagelijks functioneren ontstaan. Vaak wordt niet onderkend dat die gezondheidsklachten worden veroorzaakt door het niet goed functioneren van de biologische klok. Daardoor worden deze klachten zelden goed behandeld. Dit boek geeft inzicht hoe de biologische klok het dagelijks functioneren beïnvloedt. Het legt uit welke, meestal miskende, klachten het gevolg kunnen zijn en hoe melatonine, licht en leefwijze de biologische klok beter kunnen afstellen.
Wetenschappelijke literatuur (vaak gratis te downloaden)
Invloed van melatonine in het lichaam
Slominski RM, Reiter RJ, Schlabritz-Loutsevitch N, Ostrom RS, Slominski AT. Melatonin membrane receptors in peripheral tissues: distribution and functions. Mol Cell Endocrinol. 2012 Apr 4;351(2):152-66. doi: 10.1016/j.mce.2012.01.004. Epub 2012 Jan 8 (gratis)
Melatonine algemeen
Cipolla-Neto J & do Amaral FG. Melatonin as a hormone: new physiological and clinical insights. Endocr Rev. 2018 Sept 12. doi: 10.1210/er.2018-00084. [Epub ahead of print] Tordjman S, Chokron S, Delorme R, Charrier A, Bellissant E, Jaafari N, Fougerou C. Melatonin: Pharmacology, Functions and Therapeutic Benefits. Curr Neuropharmacol. 2017 Apr;15(3):434-443. doi: 10.2174/1570159X14666161228122115 (gratis)
Melatonine als antioxidant
Galano A, Tan DX, Reiter RJ. Melatonin: A Versatile Protector against Oxidative DNA Damage. Molecules. 2018 Feb 27;23(3). pii: E530. doi: 10.3390/molecules23030530 (gratis)
Melatonine als slaapmiddel
Auld F, Maschauer EL, Morrison I, Skene DJ, Riha RL. ‘Evidence for the efficacy of melatonin in the treatment of primary adult sleep disorders’. Sleep Med Rev. 2017 Aug;34:10-22. doi: 10.1016/j.smrv.2016.06.005. Epub 2016 Jul 20
Braam W, van Geijlswijk I, Keijzer H, Smits MG, Didden R, Curfs LM. Loss of response to melatonin treatment is associated with slow melatonin metabolism. J Intellect Disabil Res. 2010;54(6):547–555. doi:10.1111/j.1365-2788.2010.01283.x
Brzezinski A, Vangel MG, Wurtman RJ, Norrie G, Zhdanova I, Ben-Shushan A, Ford I. ‘Effects of exogenous melatonin on sleep: a meta-analysis’. Sleep Med Rev. 2005 Feb;9(1):41-50
Buscemi N, Vandermeer B, Hooton N, Pandya R, Tjosvold L, Hartling L, Baker G, Klassen TP, Vohra S. ‘The efficacy and safety of exogenous melatonin for primary sleep disorders’. A meta-analysis. J Gen Intern Med. 2005 Dec;20(12):1151-8
Buscemi N, Vandermeer B, Hooton N, Pandya R, Tjosvold L, Hartling L, Vohra S, Klassen TP, Baker G. ‘Efficacy and safety of exogenous melatonin for secondary sleep disorders and sleep disorders accompanying sleep restriction: meta-analysis’. BMJ. 2006 Feb 18;332(7538):385-93. Epub 2006 Feb 10 Cardinali DP. Melatonin: Clinical Perspectives in Neurodegeneration. Front Endocrinol (Lausanne). 2019 Jul 16;10:480. doi: 10.3389/fendo.2019.00480. eCollection 2019
Coogan AN & McGowan NM. A systematic review of circadian function, chronotype and chronotherapy in attention deficit hyperactivity disorder. Atten Defic Hyperact Disord. 2017 Sep;9(3):129-147. doi: 10.1007/s12402-016-0214-5. Epub 2017 Jan 7
Darban M, Malek F, Memarian M, Gohari A, Kiani A, Emadi A, et al. Efficacy of High Dose Vitamin C, Melatonin and Zinc in Iranian Patients with Acute Respiratory Syndrome due to Coronavirus Infection: A Pilot Randomized Trial. J Cell Mol Anesth.2021;6(2):164-7
Ettcheto M, Olloquequi J, Sánchez-López E, et al. Benzodiazepines and Related Drugs as a Risk Factor in Alzheimer’s Disease Dementia. Front Aging Neurosci. 2020;11:344. Published 2020 Jan 8. doi:10.3389/fnagi.2019.00344
Havekes R, Heckman PRA, Wams EJ, Stasiukonyte N, Meerlo P, Eisel ULM. Alzheimer’s disease pathogenesis: The role of disturbed sleep in attenuated brain plasticity and neurodegenerative processes. Cell Signal. 2019 Sep 16:109420. doi: 10.1016/j.cellsig.2019.109420. [Epub ahead of print]
Masi G, Fantozzi P, Villafranca A, Tacchi A, Ricci F, Ruglioni L, Inguaggiato E, Pfanner C, Cortese S. Effects of melatonin in children with attention-deficit/hyperactivity disorder with sleep disorders after methylphenidate treatment. Neuropsychiatr Dis Treat. 2019 Mar 7;15:663-667. doi: 10.2147/NDT.S193891. eCollection 2019
Ozguner F, Koyu A, Cesur G. Active smoking causes oxidative stress and decreases blood melatonin levels. Toxicol Ind Health. 2005;21(1-2):21–26. doi:10.1191/0748233705th211oa
Tancredi N, Kohli N. Smoking cessation and duloxetine toxicity: A case report [published online ahead of print, 2020 Feb 21]. J Am Pharm Assoc (2003). 2020;S1544-3191(20)30007-8. doi:10.1016/j.japh.2020.01.003 Standaard slaapproblemen en slaapmiddelen Nederlands Huisartsen Genootschap 2014.
Melatonine bij COVID-19
Alizadeh Z, Keyhanian N, Ghaderkhani S, Dashti-Khavidaki S, Shokouhi Shoormasti R, Pourpak Z. A Pilot Study on Controlling Coronavirus Disease 2019 (COVID-19) Inflammation Using Melatonin Supplement. Iran J Allergy Asthma Immunol. 2021 Aug 7;20(4):494-499
Brown GM, Pandi-Perumal SR, Pupko H, Kennedy JL, Cardinali DP. Melatonin as an Add-On Treatment of COVID-19 Infection: Current Status. Diseases. 2021 Sep 20;9(3):64
Cipolla-Neto J, Amaral FG, Afeche SC, Tan DX, Reiter RJ. Melatonin, energy metabolism, and obesity: a review. J Pineal Res. 2014;56(4):371-381
Darban M, Malek F, Memarian M, Gohari A, Kiani A, Emadi A, et al. Efficacy of High Dose Vitamin C, Melatonin and Zinc in Iranian Patients with Acute Respiratory Syndrome due to Coronavirus Infection: A Pilot Randomized Trial. J Cell Mol Anesth.2021;6(2):164-7
Doosti-Irani A, Ostadmohammadi V, Mirhosseini N, Mansournia MA, Reiter RJ, Kashanian M, Rahimi M, Razavi M, Asemi Z. The Effects of Melatonin Supplementation on Glycemic Control: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Horm Metab Res. 2018 Nov;50(11):783-790
Farnoosh G, Akbariqomi M, Badri T, Bagheri M, Izadi M, Saeedi-Boroujeni A, Rezaie E, Ghaleh HEG, Aghamollaei H, Fasihi-Ramandi M, Hassanpour K, Alishiri G. Efficacy of a Low Dose of Melatonin as an Adjunctive Therapy in Hospitalized Patients with COVID-19: A Randomized, Double-blind Clinical Trial. Arch Med Res. 2021 Jun 23:S0188-4409(21)00141-7
Farnoosh, G., Akbariqomi, M., Badri, T., Bagheri, M., Izadi, M., Saeedi-Boroujeni, A., Rezaie, E., Ghaleh, H.E.G., Aghamollaei, H., Fasihi Ramandi, M. et al. Efficacy of a Low Dose of Melatonin as an Adjunctive Therapy in Hospitalized Patients with COVID-19: A Randomized, Double-blind Clinical Trial. Arch. Med Res. 2021
Fogleman C, Cohen D, Mercier A, Farrell D, Rutz J, Bresz K, Vernon T. A Pilot of a Randomized Control Trial of Melatonin and Vitamin C for Mild-to-Moderate COVID-19. J Am Board Fam Med. 2022 Jul-Aug;35(4):695-707
García IG, Rodriguez-Rubio M, Mariblanca AR, et al. A randomized multicenter clinical trial to evaluate the efficacy of melatonin in the prophylaxis of SARS-CoV-2 infection in high-risk contacts (MeCOVID Trial): A structured summary of a study protocol for a randomised controlled trial. Trials. 2020;21(1):466. Published 2020 Jun 3
Han Q, Zheng B, Daines L, Sheikh A. Long-Term Sequelae of COVID-19: A Systematic Review and Meta-Analysis of One-Year Follow-Up Studies on Post-COVID Symptoms. Pathogens. 2022 Feb 19;11(2):269
Hasan ZT, Atrakji DMQYMAA, Mehuaiden DAK. The Effect of Melatonin on Thrombosis, Sepsis and Mortality Rate in COVID-19 Patients. Int J Infect Dis. 2021 Oct 12;114:79-84
Hosseini, A., Esmaeili Gouvarchin Ghaleh, H., Aghamollaei, H., Fasihi Ramandi, M., Alishiri, G., Shahriary, A., Hassanpour, K., Tat, M., Farnoosh, G. Evaluation of Th1 and Th2 mediated cellular and humoral immunity in patients with COVID-19 following the use of melatonin as an adjunctive treatment. Eur. J. Pharmacol. 2021, 904, 174193
Huang I, Lim MA, Pranata R. Diabetes mellitus is associated with increased mortality and severity of disease in COVID-19 pneumonia – A systematic review, meta-analysis, and meta-regression. Diabetes Metab Syndr. 2020 Jul-Aug;14(4):395-403
Jarrott B, Head R, Pringle KG, Lumbers ER, Martin JH. ‘LONG COVID’ – A hypothesis for understanding the biological basis and pharmacological treatment strategy. Pharmacol Res Perspect. 2022
Jehi L, Ji X, Milinovich A, et al. Individualizing risk prediction for positive COVID-19 testing: results from 11,672 patients. Chest. 2020 Oct;158(4):1364-1375Feb;10(1):e00911Lim S, Shin SM, Nam GE, Jung CH, Koo BK. Proper Management of People with Obesity during the COVID-19 Pandemic [published online ahead of print, 2020 Jun 16]. J Obes Metab Syndr. 2020;10.7570/jomes20056
Lan SH, Lee HZ, Chao CM, Chang SP, Lu LC, Lai CC. Efficacy of melatonin in the treatment of patients with COVID-19: A systematic review and meta-analysis of randomized controlled trials. J Med Virol. 2022 May;94(5):2102-2107
Lissoni P, Rovelli F, Monzon A, Messina G, Porta E, Porro G, et al. COVID-19 Disease as an Acute Angiotensin 1-7 Deficiency: A Preliminary Phase 2 Study with Angiotensin 1-7 in Association with Melatonin and Cannabidiol in Symptomatic COVID-19 Infected Subjects. J Infectiology. 2020; 3(2): 13-16
Loh D, Reiter RJ. Melatonin: Regulation of Viral Phase Separation and Epitranscriptomics in Post-Acute Sequelae of COVID-19. Int J Mol Sci. 2022 Jul 23;23(15):8122
Molina-Carballo A, Palacios-López R, Jerez-Calero A, Augustín-Morales MC, Agil A, Muñoz-Hoyos A, Muñoz-Gallego A. Protective Effect of Melatonin Administration against SARS-CoV-2 Infection: A Systematic Review. Curr Issues Mol Biol. 2021 Dec 22;44(1):31-45Mousavi SA, Heydari K, Mehravaran H, Saeedi M, Alizadeh-Navaei R, Hedayatizadeh-Omran A, Shamshirian A. Melatonin effects on sleep quality and outcomes of COVID-19 patients: An open-label, randomized, controlled trial. J Med Virol. 2022 Jan;94(1):263-271
Poly TN, Islam MM, Yang HC, Lin MC, Jian WS, Hsu MH, Jack Li YC. Obesity and Mortality Among Patients Diagnosed With COVID-19: A Systematic Review and Meta-Analysis. Front Med (Lausanne). 2021 Feb 5;8:620044. doi: 10.3389/fmed.2021.620044. PMID: 33634150; PMCID: PMC7901910
Pourhanifeh MH, Hosseinzadeh A, Dehdashtian E, Hemati K, Mehrzadi S. Melatonin: new insights on its therapeutic properties in diabetic complications. Diabetol Metab Syndr.2020 Apr 8;12:30
Scully EP, Haverfield J, Ursin RL, Tannenbaum C, Klein SL. Considering how biological sex impacts immune responses and COVID-19 outcomes . Nat Rev Immunol. 2020 Jul;20(7):442-447
Ramlall V, Zucker J, Tatonetti N. Melatonin is significantly associated with survival of intubated COVID-19 patients. medRxiv [Preprint]. 2020 Oct 18
Sánchez-González MÁ, Mahíllo-Fernández I, Villar-Álvarez F, Llanos L. What if melatonin could help COVID-19 severe patients? J Clin Sleep Med. 2021 Jul 20
Su WL, Wu CC, Wu SV, Lee MC, Liao MT, Lu KC, Lu CL. A Review of the Potential Effects of Melatonin in Compromised Mitochondrial Redox Activities in Elderly Patients With COVID-19. Front Nutr. 2022 Jun 20;9:865321
Wajid F, Poolacherla R, Mim FK, Bangash A, Rutkofsky IH. Therapeutic potential of melatonin as a chronobiotic and cytoprotective agent in diabetes mellitus. J Diabetes Metab Disord. 2020 Jul 21;19(2):1797-1825
Zhou Y, Hou Y, Shen J, Mehra R, Kallianpur A, Culver DA, Gack MU, Farha S, Zein J, Comhair S, Fiocchi C, Stappenbeck T, Chan T, Eng C, Jung JU, Jehi L, Erzurum S, Cheng F. A network medicine approach to investigation and population-based validation of disease manifestations and drug repurposing for COVID-19. PLoS Biol. 2020 Nov 6;18(11):e3000970
Melatonine bij fibromyalgie
Castaño MY, Garrido M, Rodríguez AB, Gómez MÁ. Melatonin Improves Mood Status and Quality of Life and Decreases Cortisol Levels in Fibromyalgia. Biol Res Nurs. 2019 Jan;21(1):22-29
Favero G, Bonomini F, Franco C, Rezzani R. Mitochondrial Dysfunction in Skeletal Muscle of a Fibromyalgia Model: The Potential Benefits of Melatonin. Int J Mol Sci. 2019 Feb 11;20(3)
González-Flores D, López-Pingarrón L, Castaño MY, Gómez MÁ, Rodríguez AB, García JJ, Garrido M. Melatonin as a Coadjuvant in the Treatment of Patients with Fibromyalgia. Biomedicines. 2023 Jul 12;11(7):1964
Kadijani A, Sayehmiri F, Mehrzadi S, Zabihiyeganeh M, Hosseinzadeh A, Mirzaei A. Melatonin in the treatment of fibromyalgia symptoms: A systematic review. Complement Ther Clin Pract. 2019 Nov 13;38:101072. doi: 10.1016/j.ctcp.2019.101072. [Epub ahead of print]
Coogan AN & McGowan NM. A systematic review of circadian function, chronotype and chronotherapy in attention deficit hyperactivity disorder. Atten Defic Hyperact Disord. 2017 Sep;9(3):129-147. doi: 10.1007/s12402-016-0214-5. Epub 2017 Jan 7
McDonagh MS, Holmes R, Hsu F. Pharmacologic Treatments for Sleep Disorders in Children: A Systematic Review. J Child Neurol. 2019 Jan 23:883073818821030. doi: 10.1177/0883073818821030 [Epub ahead of print]
McGowan NM, Uzoni A, Faltraco F, Thome J, Coogan AN. The impact of social jetlag and chronotype on attention, inhibition and decision making in healthy adults (published online ahead of print, 2020 Jan 14). Sleep Res. 2020;e12974. doi:10.1111/jsr.12974
Melatonine en alzheimer
Cardinali DP. Melatonin: Clinical Perspectives in Neurodegeneration. Front Endocrinol (Lausanne). 2019 Jul 16;10:480. doi: 10.3389/fendo.2019.00480. eCollection 2019
Ettcheto M, Olloquequi J, Sánchez-López E, et al. Benzodiazepines and Related Drugs as a Risk Factor in Alzheimer’s Disease Dementia. Front Aging Neurosci. 2020;11:344. Published 2020 Jan 8. doi:10.3389/fnagi.2019.00344
Havekes R, Heckman PRA, Wams EJ, Stasiukonyte N, Meerlo P, Eisel ULM. Alzheimer’s disease pathogenesis: The role of disturbed sleep in attenuated brain plasticity and neurodegenerative processes. Cell Signal. 2019 Sep 16:109420. doi: 10.1016/j.cellsig.2019.109420. [Epub ahead of print]
Spinedi E, Cardinali DP. Neuroendocrine-Metabolic Dysfunction and Sleep Disturbances in Neurodegenerative Disorders: Focus on Alzheimer’s Disease and Melatonin. Neuroendocrinology. 2019;108(4):354-364. doi: 10.1159/000494889. Epub 2018 Oct 28
Wiebe Braam, Friederike Ehrhart, Anneke P.H.M. Maas, Marcel G. Smits, Leopold Curfs. Lage melatoninespiegel bij moeder vergroot risico op autisme bij haar kind. Tijdschrift voor Artsen voor Verstandelijk Gehandicapten 2018; 36: 98-102
Braam W, Ehrhart F, Maas APHM, Smits MG, Curfs L. Low maternal melatonin level increases autism spectrum disorder risk in children. Res Dev Disabil. 2018 Feb 28. pii: S0891-4222(18)30042-8. doi: 10.1016/j.ridd.2018.02.017. [Epub ahead of print]
Williams Buckley A, Hirtz D, Oskoui M, et al. Practice guideline: Treatment for insomnia and disrupted sleep behavior in children and adolescents with autism spectrum disorder: Report of the Guideline Development, Dissemination, and Implementation Subcommittee of the American Academy of Neurology [published online ahead of print, 2020 Feb 12]. Neurology. 2020;10.1212/WNL.0000000000009033. doi:10.1212/WNL.0000000000009033
Gagnon K & Godbout R. Melatonin and Comorbidities in Children with Autism Spectrum Disorder. Curr Dev Disord Rep. 2018;5(3):197-206. doi: 10.1007/s40474-018-0147-0. Epub 2018 Aug 9.Melatonine en borstkanker
González-González A, Mediavilla MD, Sánchez-Barceló EJ. Melatonin: A Molecule for Reducing Breast Cancer Risk. Molecules. 2018 Feb 6;23(2). pii: E336. doi: 10.3390/molecules23020336 (gratis)
Ghozy S, Tran L, Naveed S, Quynh TTH, Helmy Zayan A, Waqas A, Sayed AKH, Karimzadeh S, Hirayama K, Huy NT. Association of breastfeeding status with risk of autism spectrum disorder: A systematic review, dose-response analysis and meta-analysis. Asian J Psychiatr. 2019 Dec 27;48:101916. doi: 10.1016/j.ajp.2019.101916. [Epub ahead of print] Jin Y, Choi J, Won J, Hong Y. The Relationship between Autism Spectrum Disorder and Melatonin during Fetal Development. Molecules. 2018 Jan 18;23(1). pii: E198. doi: 10.3390/molecules23010198 (gratis) Lalanne S, Fougerou-Leurent C, Anderson GM, Schroder CM, Nir T, Chokron S, Delorme R, Claustrat B, Bellissant E, Kermarrec S, Franco P, Denis L, Tordjman S. Melatonin: From Pharmacokinetics to Clinical Use in Autism Spectrum Disorder. Int J Mol Sci. 2021 Feb 2;22(3):1490 Manohar H, Pravallika M, Kandasamy P, Chandrasekaran V, Rajkumar RP. Role of Exclusive Breastfeeding in Conferring Protection in Children At-Risk for Autism Spectrum Disorder: Results from a Sibling Case-control Study. J Neurosci Rural Pract. 2018 Jan-Mar;9(1):132-136. doi: 10.4103/jnrp.jnrp_331_17 Rybnikova N, Portnov BA. Population-level study links short-wavelength nighttime illumination with breast cancer incidence in a major metropolitan area. Chronobiol Int. 2018 May 16:1-11. doi: 10.1080/07420528.2018.1466802. [Epub ahead of print]
Wu ZY, Huang SD, Zou JJ, Wang QX, Naveed M, Bao HN, Wang W, Fukunaga K, Han F. Autism spectrum disorder (ASD): Disturbance of the melatonin system and its implications. Biomed Pharmacother. 2020 Oct;130:110496
Melatonine en botten
Amstrup AK, Sikjaer T, Heickendorff L, Mosekilde L, Rejnmark L. Melatonin improves bone mineral density at the femoral neck in postmenopausal women with osteopenia: a randomized controlled trial. J Pineal Res. 2015 Sep;59(2):221-9. doi: 10.1111/jpi.12252. Epub 2015 Jun 24
Li T, Jiang S, Lu C, Yang W, Yang Z, Hu W, Xin Z, Yang Y. Melatonin: Another avenue for treating osteoporosis? J Pineal Res. 2018 Dec 29:e12548. doi: 10.1111/jpi.12548. [Epub ahead of print]
Wang B, Wen H, Smith W, Hao D, He B, Kong L. Regulation effects of melatonin on bone marrow mesenchymal stem cell differentiation. J Cell Physiol. 2019 Feb;234(2):1008-1015. doi: 10.1002/jcp.27090. Epub 2018 Aug 26
Ambrosone CB, Zirpoli GR, Hutson AD, et al. Dietary Supplement Use During Chemotherapy and Survival Outcomes of Patients With Breast Cancer Enrolled in a Cooperative Group Clinical Trial (SWOG S0221) [published online ahead of print, 2019 Dec 19]. J Clin Oncol. 2019;JCO1901203. doi:10.1200/JCO.19.01203 Amin N, Shafabakhsh R, Reiter RJ, Asemi Z. Melatonin is an appropriate candidate for breast cancer treatment: Based on known molecular mechanisms. J Cell Biochem. 2019 Aug;120(8):12208-12215. doi: 10.1002/jcb.28832. Epub 2019 Apr 3 Najafi M, Salehi E, Farhood B, Nashtaei MS, Hashemi Goradel N, Khanlarkhani N, Namjoo Z, Mortezaee K. Adjuvant chemotherapy with melatonin for targeting human cancers: A review. J Cell Physiol. 2019 Mar;234(3):2356-2372. doi: 10.1002/jcp.27259. Epub 2018 Sep 7 Palmer ACS, Souza A, Dos Santos VS, Cavalheiro JAC, Schuh F, Zucatto AE, Biazus JV, Torres ILDS, Fregni F, Caumo W. The Effects of Melatonin on the Descending Pain Inhibitory System and Neural Plasticity Markers in Breast Cancer Patients Receiving Chemotherapy: Randomized, Double-Blinded, Placebo-Controlled Trial. Front Pharmacol. 2019 Nov 22;10:1382. doi: 10.3389/fphar.2019.01382. eCollection 2019 Velicer CM, Ulrich CM. Vitamin and mineral supplement use among US adults after cancer diagnosis: a systematic review. J Clin Oncol. 2008;26(4):665-673. doi:10.1200/JCO.2007.13.5905 Zhu H, Chen Y, Bai LC, Cao XR, Xu R. Different. Effects of Melatonin on X-Rays-Irradiated Cancer Cells in a Dose-Dependent Manner. Dose Response. 2019 Sep 23;17(3):1559325819877271. doi: 10.1177/1559325819877271. eCollection 2019 Jul-Sep
Davis MP. Cannabinoids for Symptom Management and Cancer Therapy: The Evidence. J Natl Compr Canc Netw. 2016 Jul;14(7):915-22
Koch M, Dehghani F, Habazettl I, Schomerus C, Korf HW. Cannabinoids attenuate norepinephrine-induced melatonin biosynthesis in the rat pineal gland by reducing arylalkylamine N-acetyltransferase activity without involvement of cannabinoid receptors. J Neurochem. 2006 Jul;98(1):267-78
Li Y, Li S, Zhou Y, Meng X, Zhang JJ, Xu DP, Li HB. Melatonin for the prevention and treatment of cancer. Oncotarget. 2017 Jun 13;8(24):39896-39921. doi: 10.18632/oncotarget.16379
Reiter RJ, Rosales-Corral SA, Tan DX, Acuna-Castroviejo D, Qin L, Yang SF, Xu K. Melatonin, a Full Service Anti-Cancer Agent: Inhibition of Initiation, Progression and Metastasis. Int J Mol Sci. 2017 Apr 17;18(4). pii: E843. doi: 10.3390/ijms18040843
Steele G, Arneson T, Zylla D. A Comprehensive Review of Cannabis in Patients with Cancer: Availability in the USA, General Efficacy, and Safety. Curr Oncol Rep. 2019 Feb 1;21(1):10. doi: 10.1007/s11912-019-0757-7
Sagrillo-Fagundes L, Salustiano EMA, Rodrigo R, Markus RP, Vaillancourt C. Melatonin modulates autophagy and inflammation protecting human placental trophoblast from hypoxia/reoxygenation. J Pineal Res. 2018 Aug 9:e12520. doi: 10.1111/jpi.12520. [Epub ahead of print]
Santos JS, Giacheti CM, Dornelas LS, Silva NC, Souza ALDM, Guissoni Campos LM, Pinato L. Day/night melatonin content in cerebral palsy. Neurosci Lett. 2018 Aug 31. pii: S0304-3940(18)30589-5. doi: 10.1016/j.neulet.2018.08.045. [Epub ahead of print]
Daneshvar Kakhaki R, Ostadmohammadi V, Kouchaki E, Aghadavod E, Bahmani F, Tamtaji OR, J Reiter R, Mansournia MA, Asemi Z. Melatonin supplementation and the effects on clinical and metabolic status in Parkinson’s disease: A randomized, double-blind, placebo-controlled trial. Clin Neurol Neurosurg. 2020 Aug;195:105878
Iftikhar S, Sameer HM, Zainab. Significant potential of melatonin therapy in Parkinson’s disease – a meta-analysis of randomized controlled trials. Front Neurol. 2023 Oct 10;14:1265789
Li J, Liu H, Wang X, Xia Y, Huang J, Wang T, Lin Z, Xiong N. Melatonin ameliorates Parkinson’s disease via regulating microglia polarization in a RORα-dependent pathway. NPJ Parkinsons Dis. 2022 Jul 8;8(1):90
Paul R, Phukan BC, Justin Thenmozhi A, Manivasagam T, Bhattacharya P, Borah A. Melatonin protects against behavioral deficits, dopamine loss and oxidative stress in homocysteine model of Parkinson’s disease. Life Sci. 2018 Jan 1;192:238-245. doi: 10.1016/j.lfs.2017.11.016. Epub 2017 Nov 11 (gratis)
Melatonine en diabetes
Doosti-Irani A, Ostadmohammadi V, Mirhosseini N, Mansournia M, Reiter RJ, Kashanian M, Rahimi M, Razavi M, Asemi Z. The Effects of Melatonin Supplementation on Glycemic Control: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Horm Metab Res. 2018 Nov;50(11):783-790. doi: 10.1055/a-0752-8462. Epub 2018 Nov 5
Raygan F, Ostadmohammadi V, Bahmani F, Reiter RJ, Asemi Z. Melatonin administration lowers biomarkers of oxidative stress and cardio-metabolic risk in type 2 diabetic patients with coronary heart disease: A randomized, double-blind, placebo-controlled trial. Clin Nutr. 2017 Dec 12. pii: S0261-5614(17)31424-3. doi: 10.1016/j.clnu.2017.12.004. [Epub ahead of print]
Sharma S, Singh H, Ahmad N, Mishra P, Tiwari A. The role of melatonin in diabetes: therapeutic implications. Arch Endocrinol Metab. 2015 Oct;59(5):391-9. doi: 10.1590/2359-3997000000098. Epub 2015 Aug 28 (gratis)
Shimada M, Seki H, Samejima M, Hayase M, Shirai F. Salivary Melatonin levels and sleep-wake rhythms in pregnant women with hypertensive and glucose metabolic disorders: A prospective analysis. Biosci Trends. 2016 Feb;10(1):34-41. doi: 10.5582/bst.2015.01123. Epub 2016 Feb 6 (gratis)
Corpas R, Griñán-Ferré C, Palomera-Ávalos V, Porquet D, García de Frutos P, Franciscato Cozzolino SM, Rodríguez-Farré E, Pallàs M, Sanfeliu C, Cardoso BR. Melatonin induces mechanisms of brain resilience against neurodegeneration. J Pineal Res. 2018 Jun 15:e12515. doi: 10.1111/jpi.12515. [Epub ahead of print]
Jilg A, Bechstein P, Saade A, Dick M, Li TX, Tosini G, Rami A, Zemmar A, Stehle JH. Melatonin modulates daytime-dependent synaptic plasticity and learning efficiency. J Pineal Res. 2019 Jan 7:e12553. doi: 10.1111/jpi.12553. [Epub ahead of print]
Luboshitzky R, Shen-Orr Z, Tzischichinsky O, Maldonado M, Herer P, Lavie P. Actigraphic sleep-wake patterns and urinary 6-sulfatoxymelatonin excretion in patients with Alzheimer’s disease. Chronobiol Int. 2001 May;18(3):513-24
Riemersma-van der Lek RF, Swaab DF, Twisk J, Hol EM, Hoogendijk WJ, Van Someren EJ. Effect of bright light and melatonin on cognitive and noncognitive function in elderly residents of group care facilities: a randomized controlled trial. JAMA. 2008 Jun 11;299(22):2642-55. doi: 10.1001/jama.299.22.2642 (gratis) Snider KH, Sullivan KA, Obrietan K. Circadian Regulation of Hippocampal-Dependent Memory: Circuits, Synapses, and Molecular Mechanisms. Neural Plast. 2018 Feb 8;2018:7292540. doi: 10.1155/2018/7292540. eCollection 2018
Spinedi E, Cardinali DP. Neuroendocrine-Metabolic Dysfunction and Sleep Disturbances in Neurodegenerative Disorders: Focus on Alzheimer’s Disease and Melatonin. Neuroendocrinology. 2018 Oct 28. doi: 10.1159/000494889. [Epub ahead of print]
Wang YY, Zheng W, Ng CH, Ungvari GS, Wei W, Xiang YT. Meta-analysis of randomized, double-blind, placebo-controlled trials of melatonin in Alzheimer’s disease. Int J Geriatr Psychiatry. 2017 Jan;32(1):50-57. doi: 10.1002/gps.4571. Epub 2016 Sep 19
Bondy SC & Campbell A. Mechanisms Underlying Tumor Suppressive Properties of Melatonin. Int J Mol Sci. 2018 Jul 27;19(8). pii: E2205. doi: 10.3390/ijms19082205
Farhood B, Goradel NH, Mortezaee K, Khanlarkhani N, et al. Melatonin as an adjuvant in radiotherapy for radioprotection and radiosensitization. Clin Transl Oncol. 2018 Aug 22. doi: 10.1007/s12094-018-1934-0. [Epub ahead of print]
Li Y, Li S, Zhou Y, Meng X, Zhang JJ, Xu DP, Li HB. Melatonin for the prevention and treatment of cancer. Oncotarget. 2017 Jun 13;8(24):39896-39921. doi: 10.18632/oncotarget.16379 (gratis)
Reiter RJ, Rosales-Corral SA, Tan DX, Acuna-Castroviejo D, Qin L, Yang SF, Xu K. Melatonin, a Full Service Anti-Cancer Agent: Inhibition of Initiation, Progression and Metastasis. Int J Mol Sci. 2017 Apr 17;18(4). pii: E843. doi: 10.3390/ijms18040843 (gratis)
Talib WH. Melatonin and Cancer Hallmarks. Molecules. 2018 Feb 26;23(3). pii: E518. doi: 10.3390/molecules23030518 (gratis) Wang Y, Wang P, Zheng X, Du X. Therapeutic strategies of melatonin in cancer patients: a systematic review and meta-analysis. Onco Targets Ther. 2018 Nov 8;11:7895-7908. doi: 10.2147/OTT.S174100. eCollection 2018
Johnston DL, Zupanec S, Nicksy D, Morgenstern D, Narendran A, Deyell RJ, Samson Y, Wu B, Baruchel S. Phase I dose-finding study for melatonin in pediatric oncology patients with relapsed solid tumors. Pediatr Blood Cancer. 2019 Feb 20:e27676. doi: 10.1002/pbc.27676. [Epub ahead of print]
Wang Y, Wang P, Zheng X, Du X. Therapeutic strategies of melatonin in cancer patients: a systematic review and meta-analysis. Onco Targets Ther. 2018 Nov 8;11:7895-7908. doi: 10.2147/OTT.S174100. eCollection 2018
Long R, Zhu Y, Zhou S. Therapeutic role of melatonin in migraine prophylaxis: A systematic review. Medicine (Baltimore). 2019 Jan;98(3):e14099. doi: 10.1097/MD.0000000000014099
Farez MF, Calandri IL, Correale J, Quintana FJ. Anti-inflammatory effects of melatonin in multiple sclerosis. Bioessays. 2016 Oct;38(10):1016-26. doi: 10.1002/bies.201600018. Epub 2016 Aug 26
Gholipour T, Ghazizadeh T, Babapour S, Mansouri B, Ghafarpour M, Siroos B, Harirchian MH. Decreased urinary level of melatonin as a marker of disease severity in patients with multiple sclerosis. Iran J Allergy Asthma Immunol. 2015 Feb;14(1):91-7
Wurtman R. Multiple Sclerosis, Melatonin, and Neurobehavioral Diseases. Front Endocrinol (Lausanne). 2017 Oct 23;8:280. doi: 10.3389/fendo.2017.00280. eCollection 2017 Melatonine en oorsuizen Hosseinzadeh A, Kamrava SK, Moore BCJ, Reiter RJ, Ghaznavi H, Kamali M, Mehrzadi S. Molecular Aspects of Melatonin Treatment in Tinnitus; a Review. Drug Targets. 2019 Mar 19. doi: 10.2174/1389450120666190319162147. [Epub ahead of print]
Merrick L, Youssef D, Tanner M, Peiris AN. Does melatonin have therapeutic use in tinnitus? South Med J. 2014 Jun;107(6):362-6. doi: 10.14423/01.SMJ.0000450714.38550.d4 Wagenaar O, Eerste hulp bij oorsuizen, Poiesz Uitgevers, tiende druk 2019
Birder LA, Van Kerrebroeck PEV. Pathophysiological Mechanisms of Nocturia and Nocturnal Polyuria: The Contribution of Cellular Function, the Urinary Bladder Urothelium, and Circadian Rhythm. Urology. 2019 Nov;133S:14-23
Obayashi K, Saeki K, Kurumatani N. Association between melatonin secretion and nocturia in elderly individuals: a cross-sectional study of the HEIJO-KYO cohort. J Urol. 2014 Jun;191(6):1816-21
Leerasiri P, Pariyaeksut P, Hengrasmee P, Asumpinwong C. Effectiveness of melatonin for the treatment of nocturia: a randomized controlled trial. Int Urogynecol J. 2022 May 21. doi: 10.1007/s00192-022-05232-3. Epub ahead of print. PMID: 35596803
Kiddoo DA. Nocturnal enuresis. CMAJ. 2012 May 15;184(8):908-11
Merks BT, Burger H, Willemsen J, van Gool JD, de Jong TP. Melatonin treatment in children with therapy-resistant monosymptomatic nocturnal enuresis. J Pediatr Urol. 2012 Aug;8(4):416-20
Boga JA, Caballero B, Potes Y, Perez-Martinez Z, Reiter RJ, Vega-Naredo I, Coto-Montes A. Therapeutic potential of melatonin related to its role as an autophagy regulator: A review. J Pineal Res. 2018 Oct 17:e12534. doi: 10.1111/jpi.12534. [Epub ahead of print]
Lateef OM, Akintubosun MO. Sleep and Reproductive Health. J Circadian Rhythms. 2020;18:1
Sciarra F, Franceschini E, Campolo F, Gianfrilli D, Pallotti F, Paoli D, Isidori AM, Venneri MA. Disruption of Circadian Rhythms: A Crucial Factor in the Etiology of Infertility. Int J Mol Sci. 2020 May 30;21(11):3943.
Sun TC, Li HY, Li XY, Yu K, Deng SL, Tian L. Protective effects of melatonin on male fertility preservation and reproductive system [published online ahead of print, 2020 Jan 27]. Cryobiology. 2020;S0011-2240(20)30015-8. doi:10.1016/j.cryobiol.2020.01.018
Tamura H, Kawamoto M, Sato S, et al. Long-term melatonin treatment delays ovarian aging. J Pineal Res. 2017;62(2):10.1111/jpi.12381. doi:10.1111/jpi.12381
Tong J, Sheng S, Sun Y, Li H, Li WP, Zhang C, Chen ZJ. Melatonin levels in follicular fluid as markers for IVF outcomes and predicting ovarian reserve. Reproduction. 2017 Apr;153(4):443-451. doi: 10.1530/REP-16-0641. Epub 2017 Jan 6
Yong W, Ma H, Na M, Gao T, Zhang Y, Hao L, Yu H, Yang H, Deng X. Roles of melatonin in the field of reproductive medicine. Biomed Pharmacother. 2021 Dec;144:112001
Zheng M, Tong J, Li WP, Chen ZJ, Zhang C. Melatonin concentration in follicular fluid is correlated with antral follicle count (AFC) and in vitro fertilization (IVF) outcomes in women undergoing assisted reproductive technology (ART) procedures. Gynaecol Endocrinol. 2018 May;34(5):446-450. doi: 10.1080/09513590.2017.1409713. Epub 2017 Nov 29
